Effect of Intravenous Glutamine on Caspase-12 Expression in the Apoptosis of the Glomerular Epithelial Cells of Male Rats Exposed to Cisplatin

Objective: Cisplatin is potent chemotherapy for broad-spectrum malignancies treatment, but its use limited by organ toxicity effects, including nephrotoxicity. Glutamine prevents cisplatin nephrotoxicity inhibiting the oxidative stress in kidney cell apoptosis. Methods: This research examined nephroprotective effects of intravenous glutamine on glomerular epithelium male rats (Rattus norvegicus). 30 were randomly divided into (1) P0 as control group; (2) P1 that was administered with single dose (20 mg/kg BW) intraperitoneal injection; and (3) P2 injection (100 single-dose injection. The measurement caspase-12 expression apoptotic cells performed using immunohistochemical methods. Results: are follows: = 0.5 ± 0.15; 4.1 0.86; 2.54 0.72. 14.5 5.23 cells/field view; 52.7 17.06 31.5 6.73 view. There a decrease after administration white rats’ epithelial exposed to cisplatin. followed apoptosis administration. Conclusion: Immunohistochemical examination can be used marker nephrotoxic effect renal epithelium. has been observed give effects.